Alessandro M Morelli
Northern Lincolnshire and Goole NHS Foundation Trust, UK
Biography
Alessandro M Morelli carried out research in varied fields of biology, focusing in those areas most directly linked to medicine. He investigated on the enzyme Glucose-6-P-dehydrogenase and on its molecular mechanism of senescence. He has been working in the phototransduction molecular events in photoreceptor cells of vertebrate retina. He has discovered the protein FX, a NADP dependent enzyme, catalyzing synthesis of GDP-L-fucose. He has been working on the effects of electromagnetic fields of extremely low frequency on the activity of enzymes involved in phototransduction in retinal cells of vertebrates. Moreover, he has put in evidence the reversible effects of electromagnetic fields on lipid-linked enzymes such as acetylcholinesterase of retinal synaptosomes. Recently, with Isabella Panfoli, Silvia Ravera, Daniela Calzia, he has discovered the brain myelin energetic function and the ATP extramitochondrial synthesis operating in it, involving new paradigms for neurobiology, with application in the study of multiple sclerosis and other neurodegenerative diseases.
Abstract
Abstract : Metabolism of myelin in health and pathology